Mechanisms of disease: Immunopathogenesis of celiac disease

Bana Jabri, Ludvig M. Sollid

Research output: Contribution to journalReview articlepeer-review

154 Scopus citations

Abstract

Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.

Original languageEnglish
Pages (from-to)516-525
Number of pages10
JournalNature Clinical Practice Gastroenterology and Hepatology
Volume3
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

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