TY - JOUR
T1 - Mechanisms of depression
T2 - The role of neurogenesis
AU - Henn, Fritz
AU - Vollmayr, Barbara
AU - Sartorius, Alexander
PY - 2004/12
Y1 - 2004/12
N2 - The behavioral changes in depression can relate to alterations in hippocampal function. A variety of inputs to the hippocampus can effect mood, including norepinephrine (NE), serotonin (5HT) cortisol, all factors activated by stress. These are thought to act through activation of CREB neurotrophins such as BDNF. Stress has been shown to decrease hippocampal neurogenesis and most antidepressants increase neurogenesis, leading to the hypothesis that changes in the rate of new neuron formation might underlie depressive illnesses.
AB - The behavioral changes in depression can relate to alterations in hippocampal function. A variety of inputs to the hippocampus can effect mood, including norepinephrine (NE), serotonin (5HT) cortisol, all factors activated by stress. These are thought to act through activation of CREB neurotrophins such as BDNF. Stress has been shown to decrease hippocampal neurogenesis and most antidepressants increase neurogenesis, leading to the hypothesis that changes in the rate of new neuron formation might underlie depressive illnesses.
UR - http://www.scopus.com/inward/record.url?scp=21244457401&partnerID=8YFLogxK
U2 - 10.1016/j.ddmec.2004.10.007
DO - 10.1016/j.ddmec.2004.10.007
M3 - Review article
AN - SCOPUS:21244457401
SN - 1740-6765
VL - 1
SP - 407
EP - 411
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 4
ER -