Mechanisms of depression: The role of neurogenesis

Fritz Henn, Barbara Vollmayr, Alexander Sartorius

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


The behavioral changes in depression can relate to alterations in hippocampal function. A variety of inputs to the hippocampus can effect mood, including norepinephrine (NE), serotonin (5HT) cortisol, all factors activated by stress. These are thought to act through activation of CREB neurotrophins such as BDNF. Stress has been shown to decrease hippocampal neurogenesis and most antidepressants increase neurogenesis, leading to the hypothesis that changes in the rate of new neuron formation might underlie depressive illnesses.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalDrug Discovery Today: Disease Mechanisms
Issue number4
StatePublished - Dec 2004
Externally publishedYes


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