TY - JOUR
T1 - Mechanisms of colchicine effect in the treatment of asbestosis and idiopathic pulmonary fibrosis
AU - Addrizzo-Harris, D. J.
AU - Harkin, T. J.
AU - Tchou-Wong, K. M.
AU - McGuinness, G.
AU - Goldring, R.
AU - Cheng, D.
AU - Rom, D. William N.
PY - 2002
Y1 - 2002
N2 - The objective of this study was to evaluate the mechanisms of colchicine action in pulmonary fibrosis. The study included 10 patients with pulmonary fibrosis (idiopathic pulmonary fibrosis 5, asbestosis 4, and scleroderma 1) who had been admitted to Bellevue Hospital Center, a tertiary care public hospital in New York City. We administered colchicine 0.6 mg orally for 12 weeks to patients with pulmonary fibrosis. Symptoms, high resolution CT scans, pulmonary function tests, and bronchoalveolar lavage parameters were compared prior to and after treatment. Results showed declines in dyspnea index, selective improvement in several CT scans, but no statistically significant change in BAL cells, cytokines, fibronectin, or hydroxyproline. However, there was a decline in hydroxyproline in the BAL fluid in 8/10 patients. We concluded that colchicine has a mild antifibrotic effect which may be in inhibiting collagen formation since there was no effect on the inflammation that accompanies fibrosis.
AB - The objective of this study was to evaluate the mechanisms of colchicine action in pulmonary fibrosis. The study included 10 patients with pulmonary fibrosis (idiopathic pulmonary fibrosis 5, asbestosis 4, and scleroderma 1) who had been admitted to Bellevue Hospital Center, a tertiary care public hospital in New York City. We administered colchicine 0.6 mg orally for 12 weeks to patients with pulmonary fibrosis. Symptoms, high resolution CT scans, pulmonary function tests, and bronchoalveolar lavage parameters were compared prior to and after treatment. Results showed declines in dyspnea index, selective improvement in several CT scans, but no statistically significant change in BAL cells, cytokines, fibronectin, or hydroxyproline. However, there was a decline in hydroxyproline in the BAL fluid in 8/10 patients. We concluded that colchicine has a mild antifibrotic effect which may be in inhibiting collagen formation since there was no effect on the inflammation that accompanies fibrosis.
KW - Asbestosis
KW - Colchicine
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=0036460556&partnerID=8YFLogxK
U2 - 10.1007/s004080000083
DO - 10.1007/s004080000083
M3 - Article
C2 - 12172901
AN - SCOPUS:0036460556
SN - 0341-2040
VL - 180
SP - 61
EP - 72
JO - Lung
JF - Lung
IS - 2
ER -