Mechanisms and significance of brain glucose signaling in energy balance, glucose homeostasis, and food-induced reward

Kavya Devarakonda, Charles V. Mobbs

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The concept that hypothalamic glucose signaling plays an important role in regulating energy balance, e.g., as instantiated in the so-called “glucostat” hypothesis, is one of the oldest in the field of metabolism. However the mechanisms by which neurons in the hypothalamus sense glucose, and the function of glucose signaling in the brain, has been difficult to establish. Nevertheless recent studies probing mechanisms of glucose signaling have also strongly supported a role for glucose signaling in regulating energy balance, glucose homeostasis, and food-induced reward.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume438
DOIs
StatePublished - 15 Dec 2016

Keywords

  • Diabetes
  • Glucose
  • Hypothalamus
  • Obesity
  • Reward
  • Signaling

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