Abstract
The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.
| Original language | English |
|---|---|
| Pages (from-to) | 55-62 |
| Number of pages | 8 |
| Journal | Current Opinion in Genetics and Development |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1998 |
| Externally published | Yes |