TY - JOUR
T1 - Mechanical strain environment controls new bone formation during distraction osteogenesis
AU - Richards, Mark
AU - Weiss, Jeffrey A.
AU - Alsberg, Eben
AU - Shibuya, Takaaki
AU - Schaffler, Mitchell B.
AU - Goldstein, Steven A.
AU - Goulet, James A.
PY - 1996
Y1 - 1996
N2 - An animal model of distraction osteogenesis was used to investigate the effects of altered stresses and strains on tissue development, differentiation, and repair. Osteotomies were performed at 0 and 45 degrees to create different mechanical environments within the distraction gsp. Finite element simulations of functional loading and actual distractions indicated significant changes in the gap deformation field. These differences correlated with significant decreases in new bone volume and changes in trabecular architecture for the 45-degree case.
AB - An animal model of distraction osteogenesis was used to investigate the effects of altered stresses and strains on tissue development, differentiation, and repair. Osteotomies were performed at 0 and 45 degrees to create different mechanical environments within the distraction gsp. Finite element simulations of functional loading and actual distractions indicated significant changes in the gap deformation field. These differences correlated with significant decreases in new bone volume and changes in trabecular architecture for the 45-degree case.
UR - http://www.scopus.com/inward/record.url?scp=0030412499&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030412499
SN - 1071-6947
VL - 33
SP - 377
EP - 378
JO - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
JF - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
ER -