Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons

Akifumi Yogo; Katsutoshi Sato; Masaharu Nishikino; Takuya Maeda; Hironao Sakaki; Toshihiko Hori; Koichi Ogura; Mamiko Nishiuchi; Teruki Teshima; Hiroaki Nishimura; Kiminori Kondo; Paul R. Bolton; Shunichi Kawanishi

doi:10.1143/JJAP.50.106401

Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons

Akifumi Yogo, Katsutoshi Sato, Masaharu Nishikino, Takuya Maeda, Hironao Sakaki, Toshihiko Hori, Koichi Ogura, Mamiko Nishiuchi, Teruki Teshima, Hiroaki Nishimura, Kiminori Kondo, Paul R. Bolton, Shunichi Kawanishi

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7 Scopus citations

Abstract

To investigate the radiobiological effects of high dose rates that are attributed to high current, short bunch beam generation with laser-dreven ion acceleration, we have developed an experimental setup that uses laser-accelerated protons. In-vitro human lung cancer cells: A549 pulmonary adenocarcinoma are irradiated with a laser-accelerated proton bunches with a duration of 2 × 10^-8 s and flux of ∼10¹⁵ cm ^-2 s^-1, amounting to single bunch absorbed dose at the 1 Gy level. The double-strand break (DSB) yield in cell DNA is analyzed for the laser-accelerated proton beam at an average LET of 41 keV/μm.

Original language	English
Journal	Japanese Journal of Applied Physics
Volume	50
Issue number	10 PART 1
DOIs	https://doi.org/10.1143/JJAP.50.106401
State	Published - Oct 2011
Externally published	Yes

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Yogo, A., Sato, K., Nishikino, M., Maeda, T., Sakaki, H., Hori, T., Ogura, K., Nishiuchi, M., Teshima, T., Nishimura, H., Kondo, K., Bolton, P. R., & Kawanishi, S. (2011). Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons. Japanese Journal of Applied Physics, 50(10 PART 1). https://doi.org/10.1143/JJAP.50.106401

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title = "Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons",

abstract = "To investigate the radiobiological effects of high dose rates that are attributed to high current, short bunch beam generation with laser-dreven ion acceleration, we have developed an experimental setup that uses laser-accelerated protons. In-vitro human lung cancer cells: A549 pulmonary adenocarcinoma are irradiated with a laser-accelerated proton bunches with a duration of 2 × 10-8 s and flux of ∼1015 cm -2 s-1, amounting to single bunch absorbed dose at the 1 Gy level. The double-strand break (DSB) yield in cell DNA is analyzed for the laser-accelerated proton beam at an average LET of 41 keV/μm.",

author = "Akifumi Yogo and Katsutoshi Sato and Masaharu Nishikino and Takuya Maeda and Hironao Sakaki and Toshihiko Hori and Koichi Ogura and Mamiko Nishiuchi and Teruki Teshima and Hiroaki Nishimura and Kiminori Kondo and Bolton, {Paul R.} and Shunichi Kawanishi",

year = "2011",

month = oct,

doi = "10.1143/JJAP.50.106401",

language = "English",

volume = "50",

journal = "Japanese Journal of Applied Physics",

issn = "0021-4922",

number = "10 PART 1",

}

Yogo, A, Sato, K, Nishikino, M, Maeda, T, Sakaki, H, Hori, T, Ogura, K, Nishiuchi, M, Teshima, T, Nishimura, H, Kondo, K, Bolton, PR & Kawanishi, S 2011, 'Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons', Japanese Journal of Applied Physics, vol. 50, no. 10 PART 1. https://doi.org/10.1143/JJAP.50.106401

TY - JOUR

T1 - Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons

AU - Yogo, Akifumi

AU - Sato, Katsutoshi

AU - Nishikino, Masaharu

AU - Maeda, Takuya

AU - Sakaki, Hironao

AU - Hori, Toshihiko

AU - Ogura, Koichi

AU - Nishiuchi, Mamiko

AU - Teshima, Teruki

AU - Nishimura, Hiroaki

AU - Kondo, Kiminori

AU - Bolton, Paul R.

AU - Kawanishi, Shunichi

PY - 2011/10

Y1 - 2011/10

N2 - To investigate the radiobiological effects of high dose rates that are attributed to high current, short bunch beam generation with laser-dreven ion acceleration, we have developed an experimental setup that uses laser-accelerated protons. In-vitro human lung cancer cells: A549 pulmonary adenocarcinoma are irradiated with a laser-accelerated proton bunches with a duration of 2 × 10-8 s and flux of ∼1015 cm -2 s-1, amounting to single bunch absorbed dose at the 1 Gy level. The double-strand break (DSB) yield in cell DNA is analyzed for the laser-accelerated proton beam at an average LET of 41 keV/μm.

AB - To investigate the radiobiological effects of high dose rates that are attributed to high current, short bunch beam generation with laser-dreven ion acceleration, we have developed an experimental setup that uses laser-accelerated protons. In-vitro human lung cancer cells: A549 pulmonary adenocarcinoma are irradiated with a laser-accelerated proton bunches with a duration of 2 × 10-8 s and flux of ∼1015 cm -2 s-1, amounting to single bunch absorbed dose at the 1 Gy level. The double-strand break (DSB) yield in cell DNA is analyzed for the laser-accelerated proton beam at an average LET of 41 keV/μm.

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U2 - 10.1143/JJAP.50.106401

DO - 10.1143/JJAP.50.106401

M3 - Article

AN - SCOPUS:80054922284

SN - 0021-4922

VL - 50

JO - Japanese Journal of Applied Physics

JF - Japanese Journal of Applied Physics

IS - 10 PART 1

ER -

Measurement of DNA double-strand break yield in human cancer cells by high-current, short-duration bunches of laser-accelerated protons

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