Measurement of deep gray matter perfusion using a segmented true-fast imaging with steady-state precession (True-FISP) Arterial Spin-Labeling (ASL) method at 3T

Elan J. Grossman, Ke Zhang, Jing An, Abram Voorhees, Matilda Inglese, Yulin Ge, Niels Oesingmann, Jian Xu, Kelly A. Mcgorty, Qun Chen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose: To study the feasibility of using the MRI technique of segmented true-fast imaging with steady-state precession arterial spin-labeling (True-FISP ASL) for the noninvasive measurement and quantification of local perfusion in cerebral deep gray matter at 3T. Materials and Methods: A flow-sensitive alternating inversion-recovery (FAIR) ASL perfusion preparation was used in which the echo-planar imaging (EPI) readout was replaced with a segmented True-FISP data acquisition strategy. The absolute perfusion for six selected regions of deep gray matter (left and right thalamus, putamen, and caudate) were calculated in 11 healthy human subjects (six male, five female; mean age = 35.5 years ± 9.9). Results: Preliminary measurements of the average absolute perfusion values at the six selected regions of deep gray matter are in agreement with published values for mean absolute cerebral blood flow (CBF) baselines acquired from healthy volunteers using positron emission tomography (PET). Conclusion: Segmented True-FISP ASL is a practical and quantitative technique suitable to measure local tissue perfusion in cerebral deep gray matter at a high spatial resolution without the susceptibility artifacts commonly associated with EPI-based methods of ASL.

Original languageEnglish
Pages (from-to)1425-1431
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • ASL
  • Arterial spin-labeling
  • CBF
  • Cerebral blood flow
  • Cerebral perfusion
  • Deep gray matter perfusion
  • FAIR
  • Flow - sensitive alternating inversion-recovery
  • TRUE-FISP
  • True-fast imaging with steady-state precession

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