MDSCs in infectious diseases: regulation, roles, and readjustment

Anca Dorhoi, Estibaliz Glaría, Thalia Garcia-Tellez, Natalie E. Nieuwenhuizen, Gennadiy Zelinskyy, Benoit Favier, Anurag Singh, Jan Ehrchen, Cornelia Gujer, Christian Münz, Margarida Saraiva, Yahya Sohrabi, Ana E. Sousa, Peter Delputte, Michaela Müller-Trutwin, Annabel F. Valledor

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.

Original languageEnglish
Pages (from-to)673-685
Number of pages13
JournalCancer Immunology, Immunotherapy
Volume68
Issue number4
DOIs
StatePublished - 2 Apr 2019
Externally publishedYes

Keywords

  • Immunosuppression
  • Infection
  • MDSC
  • Mye-EUNITER
  • Myeloid regulatory cells
  • Oncogenic viruses

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