MDSC: Markers, development, states, and unaddressed complexity

Samarth Hegde, Andrew M. Leader, Miriam Merad

Research output: Contribution to journalReview articlepeer-review

189 Scopus citations


Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities in immunology. While the context and classification of this group of cells has evolved, MDSCs most commonly describe cells arising during chronic inflammation, especially late-stage cancers, and are defined by their T cell immunosuppressive functions. This MDSC concept has helped explain myeloid phenomena associated with disease outcome, but currently lacks clear definitions and a unifying framework across pathologies. Here, we propose such a framework to classify MDSCs as discrete cell states based on activation signals in myeloid populations leading to suppressive modes characterized by specific, measurable effects. Developing this level of knowledge of myeloid states across pathological conditions may ultimately transform how disparate diseases are grouped and treated.

Original languageEnglish
Pages (from-to)875-884
Number of pages10
Issue number5
StatePublished - 11 May 2021


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