In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause of HSPC fate alterations promoting malignancy.

Original languageEnglish
Pages (from-to)498-499
Number of pages2
JournalCell Stem Cell
Issue number4
StatePublished - 7 Apr 2022


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