Mdm2's dilemma: To degrade or to translate p53?

Pierre Jacques Hamard; James J. Manfredi

doi:10.1016/j.ccr.2011.12.018

Mdm2's dilemma: To degrade or to translate p53?

Pierre Jacques Hamard, James J. Manfredi

Research output: Contribution to journal › Short survey › peer-review

22 Scopus citations

Abstract

In this issue of Cancer Cell, Gajjar etal. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	Cancer Cell
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2011.12.018
State	Published - 17 Jan 2012

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title = "Mdm2's dilemma: To degrade or to translate p53?",

abstract = "In this issue of Cancer Cell, Gajjar etal. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.",

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AU - Manfredi, James J.

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N2 - In this issue of Cancer Cell, Gajjar etal. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.

AB - In this issue of Cancer Cell, Gajjar etal. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.

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U2 - 10.1016/j.ccr.2011.12.018

DO - 10.1016/j.ccr.2011.12.018

M3 - Short survey

AN - SCOPUS:84855934856

SN - 1535-6108

VL - 21

SP - 3

EP - 5

JO - Cancer Cell

JF - Cancer Cell

IS - 1

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Mdm2's dilemma: To degrade or to translate p53?

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