Mdm2's dilemma: To degrade or to translate p53?

Pierre Jacques Hamard, James J. Manfredi

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations


In this issue of Cancer Cell, Gajjar etal. provide insight into how Mdm2 can both inhibit and enhance p53 activity. In the basal setting, Mdm2 binds p53 and promotes p53 degradation. Under stress conditions, ATM-dependent phosphorylation of Mdm2 results in its recruitment to p53 mRNA, thereby stimulating p53 translation.

Original languageEnglish
Pages (from-to)3-5
Number of pages3
JournalCancer Cell
Issue number1
StatePublished - 17 Jan 2012


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