Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

Stephen Bohlman; James J. Manfredi

doi:10.1016/j.ccell.2016.09.017

Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

Stephen Bohlman, James J. Manfredi

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.

Original language	English
Pages (from-to)	513-514
Number of pages	2
Journal	Cancer Cell
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2016.09.017
State	Published - 10 Oct 2016

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@article{72f55baad311437e878b7182bc3f957e,

title = "Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53",

abstract = "In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.",

author = "Stephen Bohlman and Manfredi, {James J.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

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day = "10",

doi = "10.1016/j.ccell.2016.09.017",

language = "English",

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journal = "Cancer Cell",

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TY - JOUR

T1 - Mdm2-RNA Interactions as a Target for Cancer Therapy

T2 - It's Not All About p53

AU - Bohlman, Stephen

AU - Manfredi, James J.

PY - 2016/10/10

Y1 - 2016/10/10

N2 - In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.

AB - In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.

UR - http://www.scopus.com/inward/record.url?scp=84991834280&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2016.09.017

DO - 10.1016/j.ccell.2016.09.017

M3 - Short survey

C2 - 27728801

AN - SCOPUS:84991834280

SN - 1535-6108

VL - 30

SP - 513

EP - 514

JO - Cancer Cell

JF - Cancer Cell

IS - 4

ER -

Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

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