Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest

Biochemistry, Genetics and Molecular Biology

• P21 100%
• P53 100%
• Cell Cycle Arrest 100%
• Mdm2 100%
• Cell Cycle Checkpoint 100%
• Cyclin-Dependent Kinase 2 100%
• Small Interfering RNA 27%
• Downregulation 18%
• Acetylation 18%
• Doxorubicin 18%
• Promoter Region 9%
• Upregulation 9%
• Cell Cycle Progression 9%
• DNA Binding 9%
• Cell Stress 9%
• Dactinomycin 9%
• Nutlin 9%
• Serine 9%
• Lysine 9%

Keyphrases

• Cyclin-dependent Kinase 2 (CDK2) 100%
• Cell Cycle Arrest 100%
• Murine Double Minute 2 (MDM2) 100%
• Small Interfering RNA (siRNA) 50%
• Phosphorylation 33%
• Acetylation 33%
• Doxorubicin 33%
• Cell Cycle Progression 16%
• Protein Level 16%
• Transcriptional Activity 16%
• DNA Binding 16%
• Growth Arrest 16%
• P53 Protein 16%
• Cellular Stress 16%
• Lysine 16%
• Actinomycin D 16%
• Transcriptionally Active 16%
• Nutlin-3 16%
• P21 Promoter 16%
• P53 Activator 16%

Neuroscience

• P53 100%
• Cell Cycle Arrest 100%
• Cyclin Dependent Kinase 2 100%
• Cell Cycle Checkpoint 100%
• Small Interfering RNA 27%
• Acetylation 18%
• Doxorubicin 18%
• Promoter Region 9%
• Serine 9%
• DNA Binding 9%
• Growth Disorder 9%
• Lysine 9%
• Cell Cycle Progression 9%
• Cell Stress 9%
• Actinomycin 9%