MDM2 and mitochondrial function: One complex intersection

Camila Rubio-Patiño; Andrew Paul Trotta; Jerry Edward Chipuk

doi:10.1016/j.bcp.2018.10.032

MDM2 and mitochondrial function: One complex intersection

Camila Rubio-Patiño, Andrew Paul Trotta, Jerry Edward Chipuk

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.

Original language	English
Pages (from-to)	14-20
Number of pages	7
Journal	Biochemical Pharmacology
Volume	162
DOIs	https://doi.org/10.1016/j.bcp.2018.10.032
State	Published - Apr 2019

Keywords

Apoptosis
Bioenergetics
Complex I
Electron transport chain
MDM2
Mitochondria
Oncogene
Tumor suppressor
p53

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10.1016/j.bcp.2018.10.032

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title = "MDM2 and mitochondrial function: One complex intersection",

abstract = "Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.",

keywords = "Apoptosis, Bioenergetics, Complex I, Electron transport chain, MDM2, Mitochondria, Oncogene, Tumor suppressor, p53",

author = "Camila Rubio-Pati{\~n}o and Trotta, {Andrew Paul} and Chipuk, {Jerry Edward}",

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doi = "10.1016/j.bcp.2018.10.032",

language = "English",

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T1 - MDM2 and mitochondrial function

T2 - One complex intersection

AU - Rubio-Patiño, Camila

AU - Trotta, Andrew Paul

AU - Chipuk, Jerry Edward

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Y1 - 2019/4

N2 - Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.

AB - Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.

KW - Apoptosis

KW - Bioenergetics

KW - Complex I

KW - Electron transport chain

KW - MDM2

KW - Mitochondria

KW - Oncogene

KW - Tumor suppressor

KW - p53

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DO - 10.1016/j.bcp.2018.10.032

M3 - Review article

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SN - 0006-2952

VL - 162

SP - 14

EP - 20

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

ER -

MDM2 and mitochondrial function: One complex intersection

Abstract

Keywords

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