@article{0b7f3ac69e104a0f9fd572d2bee9f2f0,
title = "MDM2 and mitochondrial function: One complex intersection",
abstract = "Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.",
keywords = "Apoptosis, Bioenergetics, Complex I, Electron transport chain, MDM2, Mitochondria, Oncogene, Tumor suppressor, p53",
author = "Camila Rubio-Pati{\~n}o and Trotta, {Andrew Paul} and Chipuk, {Jerry Edward}",
note = "Funding Information: We thank everyone in the Chipuk Laboratory and the Department of Oncological Sciences. We thank Joshua R. Kaminetsky for mitochondrial imaging. This work was supported by: NIH grants R01 CA157740 (J.E.C.) and R01 CA206005 (J.E.C.); the JJR Foundation , the William A. Spivak Fund, the Fridolin Charitable Trust , an American Cancer Society Research Scholar Award, a Leukemia & Lymphoma Society Career Development Award, and an Irma T. Hirschl/Monique WeillCaulier Trust Research Award. This work was also supported in part by two research grants ( 5FY1174 and 1FY13416 ) from the March of Dimes Foundation , the Developmental Research Pilot Project Program within the Department of Oncological Sciences at the Icahn School of Medicine at Mount Sinai, and the Tisch Cancer Institute Cancer Center Support Grant ( P30 CA196521 ). Funding Information: We thank everyone in the Chipuk Laboratory and the Department of Oncological Sciences. We thank Joshua R. Kaminetsky for mitochondrial imaging. This work was supported by: NIH grants R01 CA157740 (J.E.C.) and R01 CA206005 (J.E.C.); the JJR Foundation, the William A. Spivak Fund, the Fridolin Charitable Trust, an American Cancer Society Research Scholar Award, a Leukemia & Lymphoma Society Career Development Award, and an Irma T. Hirschl/Monique Weill?Caulier Trust Research Award. This work was also supported in part by two research grants (5?FY11?74 and 1?FY13?416) from the March of Dimes Foundation, the Developmental Research Pilot Project Program within the Department of Oncological Sciences at the Icahn School of Medicine at Mount Sinai, and the Tisch Cancer Institute Cancer Center Support Grant (P30 CA196521). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = apr,
doi = "10.1016/j.bcp.2018.10.032",
language = "English",
volume = "162",
pages = "14--20",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
}