MDM2 and mitochondrial function: One complex intersection

Camila Rubio-Patiño, Andrew Paul Trotta, Jerry Edward Chipuk

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regulation of NDUFS1 (NADH:ubiquinone oxidoreductase 75 kDa Fe-S protein 1) and MT-ND6 (NADH dehydrogenase 6), MDM2 decreases the function and efficiency of Complex I (CI). These observations propose several important questions: (1) Where does MDM2 affect CI activity? (2) What are the cellular consequences of MDM2-mediated regulation of CI? (3) What are the physiological implications of these interactions? Here, we will address these questions and position these observations within the MDM2 literature.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalBiochemical Pharmacology
Volume162
DOIs
StatePublished - Apr 2019

Keywords

  • Apoptosis
  • Bioenergetics
  • Complex I
  • Electron transport chain
  • MDM2
  • Mitochondria
  • Oncogene
  • Tumor suppressor
  • p53

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