TY - JOUR
T1 - Maximum home systolic blood pressure is a marker of carotid atherosclerosis
AU - J-HOP Study Group
AU - Kaihara, Toshiki
AU - Hoshide, Satoshi
AU - Tomitani, Naoko
AU - Kanegae, Hiroshi
AU - Kario, Kazuomi
N1 - Publisher Copyright:
© 2018, © 2018 Taylor & Francis.
PY - 2019/11/17
Y1 - 2019/11/17
N2 - Background: Maximum home systolic blood pressure (maximum SBP) has been reported as a parameter of blood pressure (BP) variability. We tested the hypothesis that maximum SBP is one of the risk factors of hypertensive target organ damage (TOD). Methods: We conducted a cross-sectional study of 4,310 subjects with>1 cardiovascular risk factor. The subjects measured their home BP for 14 consecutive days. Mean and maximum SBPs were used as independent variables. As dependent variables, we used left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness (CIMT), and urine albumin creatinine ratio (UACR). Results: In a multiple regression analysis, the subjects' mean and maximum SBPs were significantly associated with the above TOD markers. Compared to mean SBP, maximum SBP demonstrated a significantly stronger association with CIMT (p<0.001). Conclusion: Based on its clinical significance herein, measurement of maximum home SBP is warranted in addition to measurement of mean home SBP.
AB - Background: Maximum home systolic blood pressure (maximum SBP) has been reported as a parameter of blood pressure (BP) variability. We tested the hypothesis that maximum SBP is one of the risk factors of hypertensive target organ damage (TOD). Methods: We conducted a cross-sectional study of 4,310 subjects with>1 cardiovascular risk factor. The subjects measured their home BP for 14 consecutive days. Mean and maximum SBPs were used as independent variables. As dependent variables, we used left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness (CIMT), and urine albumin creatinine ratio (UACR). Results: In a multiple regression analysis, the subjects' mean and maximum SBPs were significantly associated with the above TOD markers. Compared to mean SBP, maximum SBP demonstrated a significantly stronger association with CIMT (p<0.001). Conclusion: Based on its clinical significance herein, measurement of maximum home SBP is warranted in addition to measurement of mean home SBP.
KW - Blood pressure variability
KW - carotid atherosclerosis
KW - carotid intima-media thickness
KW - maximum systolic blood pressure
UR - http://www.scopus.com/inward/record.url?scp=85071967807&partnerID=8YFLogxK
U2 - 10.1080/10641963.2018.1557678
DO - 10.1080/10641963.2018.1557678
M3 - Article
C2 - 30632806
AN - SCOPUS:85071967807
SN - 1064-1963
VL - 41
SP - 774
EP - 778
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 8
ER -