Tailoring drug therapy by the application of pharmacogenetics increases the efficacy of immunosuppressive agents in patients with IBD Serial measurements of 6-thioguanine levels may optimize azathioprine/6-MP treatment without producing leukocytopenia. Patients with low to absent thiopurine methyltransferase (TPMT) enzyme activity should be immediately considered for other forms of treatment.
|Number of pages
|Clinical Perspectives in Gastroenterology
|Published - 2002