Maximizing thiopurine therapy in inflammatory bowel disease: The role of TPMT analysis and metabolite monitoring as predictors of safety and efficacy

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Abstract

Tailoring drug therapy by the application of pharmacogenetics increases the efficacy of immunosuppressive agents in patients with IBD Serial measurements of 6-thioguanine levels may optimize azathioprine/6-MP treatment without producing leukocytopenia. Patients with low to absent thiopurine methyltransferase (TPMT) enzyme activity should be immediately considered for other forms of treatment.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalClinical Perspectives in Gastroenterology
Volume5
Issue number6
StatePublished - 2002

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