TY - JOUR
T1 - Maxillary sinus mucosal blood flow during nasal vs tracheal respiration
AU - Gannon, Patrick J.
AU - Doyle, William J.
AU - Ganjian, Emil
AU - Marquez, Samuel
AU - Gnoy, Alex
AU - Gabrielle, Hilary S.
AU - Lawson, William
N1 - Funding Information:
eter,whichwas supported by National Institutes ofHealth,
PY - 1997/12
Y1 - 1997/12
N2 - Objective: To determine the effect of changes from nasal to tracheal respiration on maxillary sinus mucosal blood flow in rabbits with unobstructed sinus ostia. Design: Animals underwent tracheotomy with a T tube, and then a small window of intact maxillary sinus mucosa was exposed. Mucosal blood flow was recorded during normal nasal respiration using laser- Doppler velocimetry. At hourly intervals, respiration was changed from the nasal to the tracheal route and then back again. Subjects: Ten anesthetized rabbits were used: 5 underwent single and 4 underwent multiple shifts in the respiratory route, while 1 was monitored continuously during long-term nasal breathing only. Results: A significant decrease in maxillary sinus blood flow occurred on switching from nasal to tracheal respiration and a significant increase in blood flow occurred on return to nasal respiration. Where multiple switches were made, blood flow changes diminished in magnitude, but significant decreases (nasal to tracheal) or increases (tracheal to nasal) were evident in all cases. Conclusions: It is proposed that the maxillary sinus may act in an accessory capacity to the nose for humidification of inspired air via secretions liberated from the sinus ostium. Furthermore, we suggest that nasal airflow is involved with the reflex regulation of sinus blood flow, probably via stimulation of sensory receptors in the nasal cavity. Reduced maxillary sinus mucosal blood flow may thus contribute to supra-systemic levels of antral carbon dioxide. Since elevated carbon dioxide levels have been shown to reduce maxillary sinus mucociliary activity in vitro, nasal airflow compromise may contribute to the initiation of a cascade of pathophysiological events leading to acute sinusitis.
AB - Objective: To determine the effect of changes from nasal to tracheal respiration on maxillary sinus mucosal blood flow in rabbits with unobstructed sinus ostia. Design: Animals underwent tracheotomy with a T tube, and then a small window of intact maxillary sinus mucosa was exposed. Mucosal blood flow was recorded during normal nasal respiration using laser- Doppler velocimetry. At hourly intervals, respiration was changed from the nasal to the tracheal route and then back again. Subjects: Ten anesthetized rabbits were used: 5 underwent single and 4 underwent multiple shifts in the respiratory route, while 1 was monitored continuously during long-term nasal breathing only. Results: A significant decrease in maxillary sinus blood flow occurred on switching from nasal to tracheal respiration and a significant increase in blood flow occurred on return to nasal respiration. Where multiple switches were made, blood flow changes diminished in magnitude, but significant decreases (nasal to tracheal) or increases (tracheal to nasal) were evident in all cases. Conclusions: It is proposed that the maxillary sinus may act in an accessory capacity to the nose for humidification of inspired air via secretions liberated from the sinus ostium. Furthermore, we suggest that nasal airflow is involved with the reflex regulation of sinus blood flow, probably via stimulation of sensory receptors in the nasal cavity. Reduced maxillary sinus mucosal blood flow may thus contribute to supra-systemic levels of antral carbon dioxide. Since elevated carbon dioxide levels have been shown to reduce maxillary sinus mucociliary activity in vitro, nasal airflow compromise may contribute to the initiation of a cascade of pathophysiological events leading to acute sinusitis.
UR - http://www.scopus.com/inward/record.url?scp=0031454118&partnerID=8YFLogxK
U2 - 10.1001/archotol.1997.01900120086014
DO - 10.1001/archotol.1997.01900120086014
M3 - Article
C2 - 9413364
AN - SCOPUS:0031454118
SN - 0886-4470
VL - 123
SP - 1336
EP - 1340
JO - Archives of Otolaryngology - Head and Neck Surgery
JF - Archives of Otolaryngology - Head and Neck Surgery
IS - 12
ER -