Abstract
Combining combinatoric analysis with the Hardy-Weinberg law of genetics, it is shown that in corecessive inheritance a small number of extremely common genes could account for a much larger number of genetic subtypes (complementation groups), each one occurring in very low frequency. This analysis is developed further, and it is shown that combining Baysian analysis of these rare disorders with the Weinberg-Dahlberg equation of population genetics leads to some unexpected conclusions regarding the occurrence of disorders transmitted by corecessive inheritance in families and the tendency or lack of it for the parents of those patients to be consanguineous.
| Original language | English |
|---|---|
| Pages (from-to) | 269-271 |
| Number of pages | 3 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 11 pt 1 |
| State | Published - Nov 1989 |
| Externally published | Yes |
| Event | Images of the Twenty-First Century - Proceedings of the 11th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 - Seattle, WA, USA Duration: 9 Nov 1989 → 12 Nov 1989 |