Massive bone marrow necrosis with polyclonal hypergammaglobulinemia and blue toe syndrome

T. Murayama, Y. Hayashi, S. Imoto, M. Shimoyama, H. Matsuoka, A. Nagata, N. Iwata, T. Taniguchi, M. Ito, H. Ito, K. Chihara, T. Matsui

Research output: Contribution to journalArticlepeer-review

Abstract

Massive bone marrow necrosis was rare, and most of these cases were accompanied with malignant disease. We report a case that was thought to be idiopathic massive bone marrow necrosis. It was a 58 y.o. male who was admitted because of blue toe syndrome and hypergammaglobulinemia. We tried to detect malignant diseases with computed tomography and gallium scintigraphy, and infectious diseases with bacterial culture and viral antibodies, but all of them were negative. Pancytopenia and bone marrow necrosis was not improved, and he had died after 5-month hospitalization. Autopsy revealed massive bone marrow necrosis and bone marrow fibrosis after necrosis, but malignant or infectious diseases were not detected. It may be diagnosed as idiopathic massive bone marrow necrosis.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalHematology
Volume5
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Blue toe syndrome
  • Massive bone marrow necrosis
  • Myelofibrosis
  • Polyclonal hypergammerglobulinemia

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