Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Kazuhiko Yamada; Koji Yazawa; Akira Shimizu; Takehiro Iwanaga; Yosuke Hisashi; Matthew Nuhn; Patricia O'Malley; Shuji Nobori; Parsia A. Vagefi; Clive Patience; Jay Fishman; David K.C. Cooper; Robert J. Hawley; Julia Greenstein; Henk Jan Schuurman; Michel Awwad; Megan Sykes; David H. Sachs

doi:10.1038/nm1172

Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Kazuhiko Yamada
, Koji Yazawa
, Akira Shimizu
, Takehiro Iwanaga
, Yosuke Hisashi
, Matthew Nuhn
, Patricia O'Malley
, Shuji Nobori
, Parsia A. Vagefi
, Clive Patience
, Jay Fishman
, David K.C. Cooper
, Robert J. Hawley
, Julia Greenstein
, Henk Jan Schuurman
, Michel Awwad
, Megan Sykes
, David H. Sachs

Research output: Contribution to journal › Article › peer-review

596 Scopus citations

Abstract

The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using α-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.

Original language	English
Pages (from-to)	32-34
Number of pages	3
Journal	Nature Medicine
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/nm1172
State	Published - Jan 2005
Externally published	Yes

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Yamada, K., Yazawa, K., Shimizu, A., Iwanaga, T., Hisashi, Y., Nuhn, M., O'Malley, P., Nobori, S., Vagefi, P. A., Patience, C., Fishman, J., Cooper, D. K. C., Hawley, R. J., Greenstein, J., Schuurman, H. J., Awwad, M., Sykes, M., & Sachs, D. H. (2005). Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nature Medicine, 11(1), 32-34. https://doi.org/10.1038/nm1172

@article{e14f4c27a19e4a1ab0505769979813f9,

title = "Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue",

abstract = "The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using α-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.",

author = "Kazuhiko Yamada and Koji Yazawa and Akira Shimizu and Takehiro Iwanaga and Yosuke Hisashi and Matthew Nuhn and Patricia O'Malley and Shuji Nobori and Vagefi, \{Parsia A.\} and Clive Patience and Jay Fishman and Cooper, \{David K.C.\} and Hawley, \{Robert J.\} and Julia Greenstein and Schuurman, \{Henk Jan\} and Michel Awwad and Megan Sykes and Sachs, \{David H.\}",

note = "Funding Information: The authors wish to thank I. McMorrow for her review of the manuscript, S. Arn for herd management and quality control and M. Doherty, E. Samelson-Jones and B. Wong for help in manuscript preparation. D.H. Sachs, A. Shimizu, J. Fishman, D.K. Cooper and K. Yamada were consultants to Immerge Biotherapeutics, Inc. This work was supported in part by the US National Institutes of Health Program Project 1P01A45897 and by a Sponsored Research Agreement between the Massachusetts General hospital and Immerge Biotherapeutics, Inc.",

year = "2005",

month = jan,

doi = "10.1038/nm1172",

language = "English",

volume = "11",

pages = "32--34",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Research",

number = "1",

}

Yamada, K, Yazawa, K, Shimizu, A, Iwanaga, T, Hisashi, Y, Nuhn, M, O'Malley, P, Nobori, S, Vagefi, PA, Patience, C, Fishman, J, Cooper, DKC, Hawley, RJ, Greenstein, J, Schuurman, HJ, Awwad, M, Sykes, M & Sachs, DH 2005, 'Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue', Nature Medicine, vol. 11, no. 1, pp. 32-34. https://doi.org/10.1038/nm1172

Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. / Yamada, Kazuhiko; Yazawa, Koji; Shimizu, Akira et al.
In: Nature Medicine, Vol. 11, No. 1, 01.2005, p. 32-34.

Research output: Contribution to journal › Article › peer-review

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T1 - Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

AU - Yamada, Kazuhiko

AU - Yazawa, Koji

AU - Shimizu, Akira

AU - Iwanaga, Takehiro

AU - Hisashi, Yosuke

AU - Nuhn, Matthew

AU - O'Malley, Patricia

AU - Nobori, Shuji

AU - Vagefi, Parsia A.

AU - Patience, Clive

AU - Fishman, Jay

AU - Cooper, David K.C.

AU - Hawley, Robert J.

AU - Greenstein, Julia

AU - Schuurman, Henk Jan

AU - Awwad, Michel

AU - Sykes, Megan

AU - Sachs, David H.

N1 - Funding Information: The authors wish to thank I. McMorrow for her review of the manuscript, S. Arn for herd management and quality control and M. Doherty, E. Samelson-Jones and B. Wong for help in manuscript preparation. D.H. Sachs, A. Shimizu, J. Fishman, D.K. Cooper and K. Yamada were consultants to Immerge Biotherapeutics, Inc. This work was supported in part by the US National Institutes of Health Program Project 1P01A45897 and by a Sponsored Research Agreement between the Massachusetts General hospital and Immerge Biotherapeutics, Inc.

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AB - The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using α-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.

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JF - Nature Medicine

IS - 1

ER -

Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Abstract

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