Mapping the protein–protein and genetic interactions of cancer to guide precision medicine

Mehdi Bouhaddou, Manon Eckhardt, Zun Zar Chi Naing, Minkyu Kim, Trey Ideker, Nevan J. Krogan

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Massive efforts to sequence cancer genomes have compiled an impressive catalogue of cancer mutations, revealing the recurrent exploitation of a handful of ‘hallmark cancer pathways’. However, unraveling how sets of mutated proteins in these and other pathways hijack pro-proliferative signaling networks and dictate therapeutic responsiveness remains challenging. Here, we show that cancer driver protein–protein interactions are enriched for additional cancer drivers, highlighting the power of physical interaction maps to explain known, as well as uncover new, disease-promoting pathway interrelationships. We hypothesize that by systematically mapping the protein–protein and genetic interactions in cancer—thereby creating Cancer Cell Maps—we will create resources against which to contextualize a patient's mutations into perturbed pathways/complexes and thereby specify a matching targeted therapeutic cocktail.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume54
DOIs
StatePublished - Feb 2019
Externally publishedYes

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