Mapping of the SWAP70 gene to mouse Chromosome 7 and human Chromosome 11p15

Linda Masat, Rebecca A. Liddell, Beverly A. Mock, W. L. Kuo, Rolf Jessberger, Matthias Wabl, Herbert C. Morse

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

The protein SWAP-70 was isolated as part of a DNA recombination complex in B lymphocytes, where it is predominantly expressed. In resting B cells, SWAP-70 is found in the cytoplasm; upon B-cell activation, it is transported both into the nucleus and to the cell membrane, where it is associated with the B-cell receptor complex and may play a role in signal transduction. In the nucleus, its involvement in heavy-chain class switch recombination has been suggested. In this report, using restriction fragment length polymorphism, simple sequence length polymorphism, and fluorescence in situ hybridization, we map the chromosomal localization of the mouse and the human genes to syntenic regions of mouse mid Chromosome (Chr) 7 and human Chr 11p15.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalImmunogenetics
Volume51
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Activation
  • B lymphocytes
  • B-cell receptor
  • Heavy-chain class switch
  • Signalling protein

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