Mapping of functional activity in brain with 18F-fluoro-deoxyglucose

A. Alavi, M. Reivich, J. Greenberg, P. Hand, A. Rosenquist, W. Rintelmann, D. Christman, J. Fowler, A. Goldman, R. MacGregor, A. Wolf

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The efficacy of using the 18F-fluoro-deoxyglucose (18F-DG) for measuring regional cerebral glucose utilization in man during functional activation is demonstrated. Normal male volunteers subjected to sensory stimuli (visual, auditory, tactile) exhibited focal increases in glucose metabolism in response to the stimulus. Unilateral visual hemifield stimulation caused the contralateral striate cortex to become more active metabolically than the striate cortex ipsilateral to the stimulated hemifield. Similarly, stroking of the fingers and hand of one arm with a brush produced an increase in metabolism in the contralateral postcentral gyrus compared to the homologous ipsilateral region. The auditory stimulus, which consisted of monaural listening to either a meaningful or nonmeaningful story, caused an increase in glucose metabolism in the right temporal cortex independent of which ear was stimulated. These results demonstrat that the 18F-DG technique is capable of providing functional maps in vivo in the human brain.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalSeminars in Nuclear Medicine
Issue number1
StatePublished - Jan 1981
Externally publishedYes


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