Mapping histology to metabolism: Coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease

Michael S. Mega; Sylvia S. Chen; Paul M. Thompson; Roger P. Woods; Timur J. Karaca; Abhishek Tiwari; Harry V. Vinters; Gary W. Small; Arthur W. Toga

doi:10.1006/nimg.1996.0255

Mapping histology to metabolism: Coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease

Michael S. Mega
, Sylvia S. Chen
, Paul M. Thompson
, Roger P. Woods
, Timur J. Karaca
, Abhishek Tiwari
, Harry V. Vinters
, Gary W. Small
, Arthur W. Toga

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

The association between [¹⁸F]fluorodeoxyglucose positron emission tomography (FDG-PET) counts obtained 8 h before death and neurofibrillary tangle (NFT) staining density in a patient with Alzheimer's disease (AD) was evaluated. In our patient FDG-PET counts were globally decreased with a greater focal deficit in the left medial temporal region independent of volume loss. After death, whole-brain sections derived from cryomacrotome sectioning were stained for NFTs by the Gallyas method and elastically warped into their native space enabling registration with premortem FDG-PET data. Gallyas staining density was localized to the paralimbic cortex of the basal forebrain, medial temporal, and orbital frontal regions. The poor correlation between NFT staining density and hypometabolism on FDG-PET implicates alternate mechanisms underlying the metabolic defect in AD.

Original language	English
Pages (from-to)	147-153
Number of pages	7
Journal	NeuroImage
Volume	5
Issue number	2
DOIs	https://doi.org/10.1006/nimg.1996.0255
State	Published - Feb 1997
Externally published	Yes

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@article{bc2eb26553bf4003bb4e6beb7ff6144e,

title = "Mapping histology to metabolism: Coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease",

abstract = "The association between [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) counts obtained 8 h before death and neurofibrillary tangle (NFT) staining density in a patient with Alzheimer's disease (AD) was evaluated. In our patient FDG-PET counts were globally decreased with a greater focal deficit in the left medial temporal region independent of volume loss. After death, whole-brain sections derived from cryomacrotome sectioning were stained for NFTs by the Gallyas method and elastically warped into their native space enabling registration with premortem FDG-PET data. Gallyas staining density was localized to the paralimbic cortex of the basal forebrain, medial temporal, and orbital frontal regions. The poor correlation between NFT staining density and hypometabolism on FDG-PET implicates alternate mechanisms underlying the metabolic defect in AD.",

author = "Mega, \{Michael S.\} and Chen, \{Sylvia S.\} and Thompson, \{Paul M.\} and Woods, \{Roger P.\} and Karaca, \{Timur J.\} and Abhishek Tiwari and Vinters, \{Harry V.\} and Small, \{Gary W.\} and Toga, \{Arthur W.\}",

note = "Funding Information: Grant support for this work was provided by a VA Neuroscience Fellowship (M.S.M.), Human Brain Project (NIMH/NIDA: P20MH/DA 52176), NSF (BIR9322434), NLM (LM/MH05639), and NCRR (RR05956) (A.W.T.), and an Alzheimer{\textquoteright}s Disease Center grant (AG 10123). The authors thank Magnus Dahlbom, Ph.D., in the Department of Nuclear Medicine; the members of the Laboratory of Neuro Imaging, especially Andrew Lee for assisting with the production of the 3D surface model; and the members of the Section of Neuropathology. Special appreciation goes to the family of the patient for their kindness and accommodation.",

year = "1997",

month = feb,

doi = "10.1006/nimg.1996.0255",

language = "English",

volume = "5",

pages = "147--153",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press Inc.",

number = "2",

}

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T1 - Mapping histology to metabolism

T2 - Coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease

AU - Mega, Michael S.

AU - Chen, Sylvia S.

AU - Thompson, Paul M.

AU - Woods, Roger P.

AU - Karaca, Timur J.

AU - Tiwari, Abhishek

AU - Vinters, Harry V.

AU - Small, Gary W.

AU - Toga, Arthur W.

N1 - Funding Information: Grant support for this work was provided by a VA Neuroscience Fellowship (M.S.M.), Human Brain Project (NIMH/NIDA: P20MH/DA 52176), NSF (BIR9322434), NLM (LM/MH05639), and NCRR (RR05956) (A.W.T.), and an Alzheimer’s Disease Center grant (AG 10123). The authors thank Magnus Dahlbom, Ph.D., in the Department of Nuclear Medicine; the members of the Laboratory of Neuro Imaging, especially Andrew Lee for assisting with the production of the 3D surface model; and the members of the Section of Neuropathology. Special appreciation goes to the family of the patient for their kindness and accommodation.

PY - 1997/2

Y1 - 1997/2

N2 - The association between [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) counts obtained 8 h before death and neurofibrillary tangle (NFT) staining density in a patient with Alzheimer's disease (AD) was evaluated. In our patient FDG-PET counts were globally decreased with a greater focal deficit in the left medial temporal region independent of volume loss. After death, whole-brain sections derived from cryomacrotome sectioning were stained for NFTs by the Gallyas method and elastically warped into their native space enabling registration with premortem FDG-PET data. Gallyas staining density was localized to the paralimbic cortex of the basal forebrain, medial temporal, and orbital frontal regions. The poor correlation between NFT staining density and hypometabolism on FDG-PET implicates alternate mechanisms underlying the metabolic defect in AD.

AB - The association between [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) counts obtained 8 h before death and neurofibrillary tangle (NFT) staining density in a patient with Alzheimer's disease (AD) was evaluated. In our patient FDG-PET counts were globally decreased with a greater focal deficit in the left medial temporal region independent of volume loss. After death, whole-brain sections derived from cryomacrotome sectioning were stained for NFTs by the Gallyas method and elastically warped into their native space enabling registration with premortem FDG-PET data. Gallyas staining density was localized to the paralimbic cortex of the basal forebrain, medial temporal, and orbital frontal regions. The poor correlation between NFT staining density and hypometabolism on FDG-PET implicates alternate mechanisms underlying the metabolic defect in AD.

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DO - 10.1006/nimg.1996.0255

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AN - SCOPUS:0031074962

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SP - 147

EP - 153

JO - NeuroImage

JF - NeuroImage

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ER -

Mapping histology to metabolism: Coregistration of stained whole-brain sections to premortem PET in Alzheimer's disease

Abstract

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