Mapping hippocampal atrophy with a multi-scale model of shape

Xinyang Liu, Yonggang Shi, Jonathan Morra, Xiuwen Liu, Paul Thompson, Washington Mio

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

We construct a multi-scale model of shape of surfaces in 3D space based on the heat kernel associated with the Laplace-Beltrami operator. The model is applied to the analysis of longitudinal neuroimaging data collected by the Alzheimer's Disease Neuroimaging Initiative. We use measures of shape deformation energy to quantify, compare and create maps of regional changes in hippocampal shape in normal aging, progression of Alzheimer's disease and mild cognitive impairment over a one-year period.

Original languageEnglish
Title of host publicationProceedings - 2009 IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2009
Pages879-882
Number of pages4
DOIs
StatePublished - 2009
Externally publishedYes
Event2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009 - Boston, MA, United States
Duration: 28 Jun 20091 Jul 2009

Publication series

NameProceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009

Conference

Conference2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009
Country/TerritoryUnited States
CityBoston, MA
Period28/06/091/07/09

Keywords

  • Shape space, heat kernel, hippocampal atrophy, Alzheimer's disease, ADNI.

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