Mapping genes for psychiatric disorders and behavioral traits

L. Alison McInnes; Nelson B. Freimer

doi:10.1016/0959-437X(95)80054-9

Mapping genes for psychiatric disorders and behavioral traits

L. Alison McInnes
, Nelson B. Freimer

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In the past year, some of the most exciting findings in the genetic investigation of mammalian behavior have been obtained through mapping and through gene manipulation studies in the mouse systems. These include the localization of a gene for circadian periodicity in the mouse, gene knockouts of serotonin receptors, and the development of a transgenic model of Alzheimer's disease. The recent development of genetic maps covering the entire human genome and the implementation of new approaches to genetic analysis may now facilitate elucidation of complex behaviors in humans, particularly psychiatric disorders.

Original language	English
Pages (from-to)	376-381
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/0959-437X(95)80054-9
State	Published - Jun 1995
Externally published	Yes

Keywords

5HT-hydroxytryptamine
APM-affected pedigree member
BP-bipolar disorder
ENU-N-ethyl-N-nitrosurea
IBD-identical by descent
IBS-identical by state
MOA-A-monoamine oxidase type A
QTL-quantitative trait locus

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10.1016/0959-437X(95)80054-9

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title = "Mapping genes for psychiatric disorders and behavioral traits",

abstract = "In the past year, some of the most exciting findings in the genetic investigation of mammalian behavior have been obtained through mapping and through gene manipulation studies in the mouse systems. These include the localization of a gene for circadian periodicity in the mouse, gene knockouts of serotonin receptors, and the development of a transgenic model of Alzheimer's disease. The recent development of genetic maps covering the entire human genome and the implementation of new approaches to genetic analysis may now facilitate elucidation of complex behaviors in humans, particularly psychiatric disorders.",

keywords = "5HT-hydroxytryptamine, APM-affected pedigree member, BP-bipolar disorder, ENU-N-ethyl-N-nitrosurea, IBD-identical by descent, IBS-identical by state, MOA-A-monoamine oxidase type A, QTL-quantitative trait locus",

author = "McInnes, \{L. Alison\} and Freimer, \{Nelson B.\}",

year = "1995",

month = jun,

doi = "10.1016/0959-437X(95)80054-9",

language = "English",

volume = "5",

pages = "376--381",

journal = "Current Opinion in Genetics and Development",

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publisher = "Elsevier Ltd.",

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T1 - Mapping genes for psychiatric disorders and behavioral traits

AU - McInnes, L. Alison

AU - Freimer, Nelson B.

PY - 1995/6

Y1 - 1995/6

N2 - In the past year, some of the most exciting findings in the genetic investigation of mammalian behavior have been obtained through mapping and through gene manipulation studies in the mouse systems. These include the localization of a gene for circadian periodicity in the mouse, gene knockouts of serotonin receptors, and the development of a transgenic model of Alzheimer's disease. The recent development of genetic maps covering the entire human genome and the implementation of new approaches to genetic analysis may now facilitate elucidation of complex behaviors in humans, particularly psychiatric disorders.

AB - In the past year, some of the most exciting findings in the genetic investigation of mammalian behavior have been obtained through mapping and through gene manipulation studies in the mouse systems. These include the localization of a gene for circadian periodicity in the mouse, gene knockouts of serotonin receptors, and the development of a transgenic model of Alzheimer's disease. The recent development of genetic maps covering the entire human genome and the implementation of new approaches to genetic analysis may now facilitate elucidation of complex behaviors in humans, particularly psychiatric disorders.

KW - 5HT-hydroxytryptamine

KW - APM-affected pedigree member

KW - BP-bipolar disorder

KW - ENU-N-ethyl-N-nitrosurea

KW - IBD-identical by descent

KW - IBS-identical by state

KW - MOA-A-monoamine oxidase type A

KW - QTL-quantitative trait locus

UR - https://www.scopus.com/pages/publications/0029058696

U2 - 10.1016/0959-437X(95)80054-9

DO - 10.1016/0959-437X(95)80054-9

M3 - Article

C2 - 7549434

AN - SCOPUS:0029058696

SN - 0959-437X

VL - 5

SP - 376

EP - 381

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 3

ER -

Mapping genes for psychiatric disorders and behavioral traits

Abstract

Keywords

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