Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure

Elizabeth D. O'Hare; Eric Kan; June Yoshii; Sarah N. Mattson; Edward P. Riley; Paul M. Thompson; Arthur W. Toga; Elizabeth R. Sowell

doi:10.1097/01.wnr.0000176515.11723.a2

Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure

Elizabeth D. O'Hare, Eric Kan, June Yoshii, Sarah N. Mattson, Edward P. Riley, Paul M. Thompson, Arthur W. Toga, Elizabeth R. Sowell

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive deficits. High-resolution magnetic resonance imaging, surface-based image analytic methods, and neuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermal morphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically significant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and significant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology.

Original language	English
Pages (from-to)	1285-1290
Number of pages	6
Journal	NeuroReport
Volume	16
Issue number	12
DOIs	https://doi.org/10.1097/01.wnr.0000176515.11723.a2
State	Published - 22 Aug 2005
Externally published	Yes

Keywords

Cerebellum
Prenatal alcohol exposure
Structural magnetic resonance imaging
Verbal learning and memory

Access to Document

10.1097/01.wnr.0000176515.11723.a2

Cite this

@article{1be9166a039c4ddbbdfafde7a596187e,

title = "Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure",

abstract = "Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive deficits. High-resolution magnetic resonance imaging, surface-based image analytic methods, and neuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermal morphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically significant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and significant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology.",

keywords = "Cerebellum, Prenatal alcohol exposure, Structural magnetic resonance imaging, Verbal learning and memory",

author = "O'Hare, {Elizabeth D.} and Eric Kan and June Yoshii and Mattson, {Sarah N.} and Riley, {Edward P.} and Thompson, {Paul M.} and Toga, {Arthur W.} and Sowell, {Elizabeth R.}",

year = "2005",

month = aug,

day = "22",

doi = "10.1097/01.wnr.0000176515.11723.a2",

language = "English",

volume = "16",

pages = "1285--1290",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure

AU - O'Hare, Elizabeth D.

AU - Kan, Eric

AU - Yoshii, June

AU - Mattson, Sarah N.

AU - Riley, Edward P.

AU - Thompson, Paul M.

AU - Toga, Arthur W.

AU - Sowell, Elizabeth R.

PY - 2005/8/22

Y1 - 2005/8/22

N2 - Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive deficits. High-resolution magnetic resonance imaging, surface-based image analytic methods, and neuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermal morphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically significant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and significant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology.

AB - Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive deficits. High-resolution magnetic resonance imaging, surface-based image analytic methods, and neuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermal morphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically significant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and significant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology.

KW - Cerebellum

KW - Prenatal alcohol exposure

KW - Structural magnetic resonance imaging

KW - Verbal learning and memory

UR - http://www.scopus.com/inward/record.url?scp=24044474729&partnerID=8YFLogxK

U2 - 10.1097/01.wnr.0000176515.11723.a2

DO - 10.1097/01.wnr.0000176515.11723.a2

M3 - Article

C2 - 16056126

AN - SCOPUS:24044474729

SN - 0959-4965

VL - 16

SP - 1285

EP - 1290

JO - NeuroReport

JF - NeuroReport

IS - 12

ER -

Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure

Abstract

Keywords

Access to Document

Fingerprint

Cite this