TY - JOUR
T1 - Mapping brain asymmetry
AU - Toga, Arthur W.
AU - Thompson, Paul M.
N1 - Funding Information:
Grant support was provided by a P41 Resource Grant from the National Center for Research Resources. Further support for algorithm development was provided by the National Library of Medicine, the National Institute of Mental Health, and by a Human Brain Project grant to the International Consortium for Brain Mapping, funded jointly by the National Institute of Mental Health and the National Institute on Drug Abuse.
PY - 2003/1
Y1 - 2003/1
N2 - Brain asymmetry has been observed in animals and humans in terms of structure, function and behaviour. This lateralization is thought to reflect evolutionary, hereditary, developmental, experiential and pathological factors. Here, we review the diverse literature describing brain asymmetries, focusing primarily on anatomical differences between the hemispheres and the methods that have been used to detect them. Brain-mapping approaches, in particular, can identify and visualize patterns of asymmetry in whole populations, including subtle alterations that occur in disease, with age and during development. These and other tools show great promise for assessing factors that modulate cognitive specialization in the brain, including the ontogeny, phylogeny and genetic determinants of brain asymmetry.
AB - Brain asymmetry has been observed in animals and humans in terms of structure, function and behaviour. This lateralization is thought to reflect evolutionary, hereditary, developmental, experiential and pathological factors. Here, we review the diverse literature describing brain asymmetries, focusing primarily on anatomical differences between the hemispheres and the methods that have been used to detect them. Brain-mapping approaches, in particular, can identify and visualize patterns of asymmetry in whole populations, including subtle alterations that occur in disease, with age and during development. These and other tools show great promise for assessing factors that modulate cognitive specialization in the brain, including the ontogeny, phylogeny and genetic determinants of brain asymmetry.
UR - https://www.scopus.com/pages/publications/0037264651
U2 - 10.1038/nrn1009
DO - 10.1038/nrn1009
M3 - Article
C2 - 12511860
AN - SCOPUS:0037264651
SN - 1471-003X
VL - 4
SP - 37
EP - 48
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 1
ER -