Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease

Michael S. Mega, Teresa Chu, John C. Mazziotta, Kashyap H. Trivedi, Paul M. Thompson, Amish Shah, Gregory Cole, Sally A. Frautschy, Arthur W. Toga

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We evaluated the relationship between amyloid-β protein (Aβ) concentration and the metabolic abnormality in an Alzheimer's disease (AD) patient as measured by [18F]fluorodeoxyglucose positron emission tomography (FDG-PET). Across most regions there were significant inverse correlations among FDG-PET intensity values and both insoluble. The temporal lobe samples showed no significant correlation between FDG-PET values and Aβ deposition. Findings support Aβ as contributing to the hypometabolism in regions of the AD brain that are still relatively viable metabolically; those regions with chronic pathologic damage, such as temporal cortex, may have other factors that contribute to metabolic deficits.

Original languageEnglish
Pages (from-to)2911-2917
Number of pages7
JournalNeuroReport
Volume10
Issue number14
DOIs
StatePublished - 29 Sep 1999
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid protein
  • Brain mapping
  • PET

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