Mapping age effects along fiber tracts in young adults

Emily L. Dennis, Faisal Rashid, Josh Faskowitz, Yan Jin, Katie L. McMahon, Greig I. De Zubicaray, Nicholas G. Martin, Ian B. Hickie, Margaret J. Wright, Neda Jahanshad, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Brain development is a protracted and dynamic process. Many studies have charted the trajectory of white matter development, but here we sought to map these effects in greater detail, based on a large set of fiber tracts automatically extracted from HARDI (high angular resolution diffusion imaging) at 4 tesla. We used autoMATE (automated multi-atlas tract extraction) to extract diffusivity measures along 18 of the brain's major fiber bundles in 667 young adults, aged 18-30. We examined linear and non-linear age effects on diffusivity measures, pointwise along tracts. All diffusivity measures showed both linear and non-linear age effects. Tracts with the most pronounced age effects were those that connected the temporal lobe to the rest of the brain. Nonlinear age effects were picked up strongly in the anterior corpus callosum and right temporo-parietal tracts.

Original languageEnglish
Title of host publication2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781509011711
StatePublished - 15 Jun 2017
Externally publishedYes
Event14th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia
Duration: 18 Apr 201721 Apr 2017

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Conference14th IEEE International Symposium on Biomedical Imaging, ISBI 2017


  • Development
  • Diffusion weighted imaging
  • Structural connectivity
  • Tractography


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