MAPK and PI3K signaling: At the crossroads of neural crest development

Colin J. Dinsmore, Philippe Soriano

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Receptor tyrosine kinase-mediated growth factor signaling is essential for proper formation and development of the neural crest. The many ligands and receptors implicated in these processes signal through relatively few downstream pathways, frequently converging on the MAPK and PI3K pathways. Despite decades of study, there is still considerable uncertainty about where and when these signaling pathways are required and how they elicit particular responses. This review summarizes our current understanding of growth factor-induced MAPK and PI3K signaling in the neural crest.

Original languageEnglish
Pages (from-to)S79-S97
JournalDevelopmental Biology
StatePublished - 1 Dec 2018


  • AKT
  • Cell signaling
  • ERK
  • Receptor Tyrosine kinases


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