TY - JOUR
T1 - Many faces, many places
T2 - delving deeper into CAF heterogeneity in NSCLC
AU - Papavassiliou, Kostas A.
AU - Adamopoulos, Christos
AU - Papavassiliou, Athanasios G.
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/4
Y1 - 2024/4
N2 - In a recent study published in Cancer Cell, Cords et al. employed multiplexed imaging mass cytometry to analyze cancer-associated fibroblast (CAF) heterogeneity in 1070 NSCLC patients. This work defined good and poor prognostic CAF phenotypes, the latter associated with metastasis and chemoresistance, as well as revealed that CAF spatial location correlates with immune cell infiltration and clinical outcome.
AB - In a recent study published in Cancer Cell, Cords et al. employed multiplexed imaging mass cytometry to analyze cancer-associated fibroblast (CAF) heterogeneity in 1070 NSCLC patients. This work defined good and poor prognostic CAF phenotypes, the latter associated with metastasis and chemoresistance, as well as revealed that CAF spatial location correlates with immune cell infiltration and clinical outcome.
KW - cancer-associated fibroblasts
KW - non-small cell lung cancer
KW - phenotypes
KW - prognosis
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85186078136&partnerID=8YFLogxK
U2 - 10.1016/j.trecan.2024.02.004
DO - 10.1016/j.trecan.2024.02.004
M3 - Short survey
C2 - 38395732
AN - SCOPUS:85186078136
SN - 2405-8033
VL - 10
SP - 277
EP - 279
JO - Trends in Cancer
JF - Trends in Cancer
IS - 4
ER -