The diseases which Mikulicz syndrome comprises can be differentiated from the autoimmune pseudosialectasias in almost all cases purely on the basis of the sialogram. This is because the sialographic changes of the autoimmune diseases have a unique appearance which no other pathologic process simulates either histologically or radiographically. This is very important when one realizes that in many instances the clinician cannot differentiate between Mikulicz syndrome and the autoimmune pseudosialectasias. This paper reviews the diseases included in Mikulicz syndrome, demonstrates their sialographic findings, and relates the clinical information that might assist in further differentiation of these entities. Information gained by CT-sialography will be emphasized. There are three main clinicopathologic presentations of Mikulicz syndrome: chronic recurrent sialadenitis, parotid sialosis, and the multinodular parotid gland. Each clinical presentation can be mimicked by the autoimmune diseases. It is this very problem that prompted this study. The sialographic appearance differentiates the autoimmune from the non-autoimmune diseases. Further, it can differentiate between sialadenitis, sialosis, and the nonautoimmune multinodular gland. Each of these three entities will be discussed in turn.