Manifestations digestives des allergies alimentaires chez l'adulte

Translated title of the contribution: Food allergy and the gut in adults

B. Mesnard, P. Desreumaux, J. F. Colombel

Research output: Contribution to journalReview articlepeer-review

Abstract

Food allergy, synonymous with food hypersensitivity (FHS), is defined as an immunologically-mediated adverse reaction to food. Initiation of FHS could result from a break in the immune mucosal barrier with abrogation of oral tolerance. Food hypersensitivity is mostly due to immediate-type reaction involving IgE-dependent mastocytes activation. Changes in intestinal function and structure have been mainly studies in an animal model of rat sensitized to egg albumin. Intraluminal antigen challenge resulted in abnormalities of gut absorption, secretion and motility in sensitized rats. In man, experimental data are scarce. Gastrointestinal manifestations of immediate FHS are varying and unspecific. A role for FHS in irritable bowel syndrome is debated. Participation of delayed-type FHS to digestive diseases is still questionable, but eosinophilic gastroenteritis might be an example. In clinical practice, diagnosis of FHS demands rigorous criteria. Double blind placebo-controlled food challenge has eventually proved to be the « gold standardtest for FHS diagnosis.

Translated title of the contributionFood allergy and the gut in adults
Original languageFrench
Pages (from-to)289-294
Number of pages6
JournalRevue de Medecine Interne
Volume12
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • EOSINOPHILIC GASTROENTERITIS
  • FOOD CHALLENGE
  • FOOD HYPERSENSITIVITY
  • IRRITABLE BOWEL SYNDROME
  • MASTOCYTE

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