Mania after brain injury: Neuroradiological and metabolic findings

Sergio E. Starkstein, Helen S. Mayberg, Marcelo L. Berthier, Paul Fedoroff, Thomas R. Price, Robert F. Dannals, Henry N. Wagner, Ramon Leiguarda, Robert G. Robinson

Research output: Contribution to journalArticlepeer-review

187 Scopus citations


We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). while the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a 18fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.

Original languageEnglish
Pages (from-to)652-659
Number of pages8
JournalAnnals of Neurology
Issue number6
StatePublished - Jun 1990
Externally publishedYes


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