Managing anticoagulation in patients with mechanical valves

Usman Baber, Nilusha Gukathasan, Valentin Fuster

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


As the burden of valvular heart disease increases worldwide, surgical valve replacement with mechanical prostheses continues to be an important treatment option for thousands of patients each year. All patients with mechanical heart valves require oral anticoagulation with vitamin K antagonists. The optimal dose and intensity of anticoagulation depends on patient- and valve-related risk factors. Clinical management is further complicated during pregnancy or surgery because antithrombotic therapy may need to be altered and decisions are often based on limited, observational data. Novel therapies that may overcome many of the inherent limitations associated with vitamin K antagonists are currently being developed and tested as alternative anticoagulants in different patient populations.

Original languageEnglish
Title of host publicationEvidence-Based Cardiology Consult
PublisherSpringer-Verlag London Ltd
Number of pages11
ISBN (Electronic)9781447144410
ISBN (Print)1447144406, 9781447144403
StatePublished - 1 Nov 2014


  • Anticoagulation
  • Mechanical heart valves
  • Perioperative management
  • Pregnancy
  • Valvular heart disease
  • Vitamin K antagonists


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