Management of small hepatocellular carcinoma in cirrhosis: Focus on portal hypertension

Virginia Hernandez-Gea, Fanny Turon, Annalisa Berzigotti, Augusto Villanueva

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The incidence of hepatocellular carcinoma (HCC) is rising worldwide being currently the fifth most common cancer and third cause of cancer-related mortality. Early detection of HCC through surveillance programs have enabled the identification of small nodules with higher frequency, and nowadays account for 10%-15% of patients diagnosed in the West and almost 30% in Japan. Patients with small HCC can be candidates for potential curative treatments: liver transplantation, surgical resection and percutaneous ablation, depending on the presence of portal hypertension and co-morbidities. This review will analyze recent advancements in the clinical management of these individuals, focusing on issues related to the role of portal hypertension, the debate between resection and ablative therapies and the future impact of molecular technologies.

Original languageEnglish
Pages (from-to)1193-1199
Number of pages7
JournalWorld Journal of Gastroenterology
Issue number8
StatePublished - 2013
Externally publishedYes


  • Clinically significant portal hypertension
  • Hepatic venous pressure gradient
  • Hepatocellular carcinoma
  • Liver cancer
  • Liver stiffness
  • Percutaneous ethanol injection
  • Portal hypertension
  • Radiofrequency ablation
  • Resection


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