TY - JOUR
T1 - Management of osteoporosis in survivors of adult cancers with nonmetastatic disease
T2 - ASCO clinical practice guideline
AU - Shapiro, Charles L.
AU - Van Poznak, Catherine
AU - Lacchetti, Christina
AU - Kirshner, Jeffrey
AU - Eastell, Richard
AU - Gagel, Robert
AU - Smith, Sean
AU - Edwards, Beatrice J.
AU - Frank, Elizabeth
AU - Lyman, Gary H.
AU - Smith, Matthew R.
AU - Mhaskar, Rahul
AU - Henderson, Tara
AU - Neuner, Joan
N1 - Publisher Copyright:
© 2019 by American Society of Clinical Oncology
PY - 2019
Y1 - 2019
N2 - PURPOSE: The aim of this work is to provide evidence-based guidance on the management of osteoporosis in survivors of adult cancer. METHODS: ASCO convened a multidisciplinary Expert Panel to develop guideline recommendations based on a systematic review of the literature. RESULTS: The literature search of the 2018 systematic review by the US Preventive Services Task Force in the noncancer population was used as the evidentiary base upon which the Expert Panel based many of its recommendations. A total of 61 additional studies on topics and populations not covered in the US Preventive Services Task Force review were also included. Patients with cancer with metastatic disease and cancer survival outcomes related to bone-modifying agents are not included in this guideline. RECOMMENDATIONS: Patients with nonmetastatic cancer may be at risk for osteoporotic fractures due to baseline risks or due to the added risks that are associated with their cancer therapy. Clinicians are advised to assess fracture risk using established tools. For those patients with substantial risk of osteoporotic fracture, the clinician should obtain a bone mineral density test. The bone health of all patients may benefit from optimizing nutrition, exercise, and lifestyle. When a pharmacologic agent is indicated, bisphosphonates or denosumab at osteoporosis-indicated dosages are the preferred interventions.
AB - PURPOSE: The aim of this work is to provide evidence-based guidance on the management of osteoporosis in survivors of adult cancer. METHODS: ASCO convened a multidisciplinary Expert Panel to develop guideline recommendations based on a systematic review of the literature. RESULTS: The literature search of the 2018 systematic review by the US Preventive Services Task Force in the noncancer population was used as the evidentiary base upon which the Expert Panel based many of its recommendations. A total of 61 additional studies on topics and populations not covered in the US Preventive Services Task Force review were also included. Patients with cancer with metastatic disease and cancer survival outcomes related to bone-modifying agents are not included in this guideline. RECOMMENDATIONS: Patients with nonmetastatic cancer may be at risk for osteoporotic fractures due to baseline risks or due to the added risks that are associated with their cancer therapy. Clinicians are advised to assess fracture risk using established tools. For those patients with substantial risk of osteoporotic fracture, the clinician should obtain a bone mineral density test. The bone health of all patients may benefit from optimizing nutrition, exercise, and lifestyle. When a pharmacologic agent is indicated, bisphosphonates or denosumab at osteoporosis-indicated dosages are the preferred interventions.
UR - http://www.scopus.com/inward/record.url?scp=85074306487&partnerID=8YFLogxK
U2 - 10.1200/JCO.19.01696
DO - 10.1200/JCO.19.01696
M3 - Article
C2 - 31532726
AN - SCOPUS:85074306487
SN - 0732-183X
VL - 37
SP - 2916
EP - 2946
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 31
ER -