Management of congenital adrenal hyperplasia: Beyond conventional glucocorticoid therapy

Ahmed Khattab, Ian Marshall

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Purpose of review The most common enzyme defect associated with congenital adrenal hyperplasia (CAH) is 21-hydroxylase deficiency (21OHD). Glucocorticoid therapy aiming to suppress adrenocorticotrophic hormone (ACTH)mediated hyperandrogenemia and to replace glucocorticoid deficiency, if indicated, remains the first line of management in CAH with or without mineralocorticoid replacement therapy and salt supplementation. We review interventions that may address unmet needs in the management of CAH. Although the objective of this review is to highlight some potential benefits of supplemental therapies, the authors do not recommend for or against the use of the reviewed therapies. In the review, the terms ‘male’ and ‘female’ refer to ‘genetic male (46,XY)’ and ‘genetic female (46,XX)’ respectively. Recent findings Supplemental therapies, some of which appear to be promising, attempt to address CAH-associated morbidity but long-term efficacy and safety data are still lacking. Summary We highlight main ideas behind the use of interventions that target an improvement in physiological glucocorticoid replacement, adult height outcome, and management of female genital virilization in CAH.

Original languageEnglish
Pages (from-to)550-554
Number of pages5
JournalCurrent Opinion in Pediatrics
Issue number4
StatePublished - 1 Aug 2019
Externally publishedYes


  • Congenital adrenal hyperplasia
  • Prenatal
  • Treatment


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