Management of concomitant hepatocellular carcinoma and chronic hepatitis C: a review

Elizabeth Harrod, Carlos Moctezuma-Velazquez, Ahmet Gurakar, Aftab Ala, Douglas Dieterich, Behnam Saberi

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Our comprehensive review focuses on the treatment of hepatitis C virus in the context of hepatocellular carcinoma and vice versa, highlighting the ongoing complexity of this clinical scenario. There remain multiple unanswered questions when considering the management of these complex patients and, with a rapidly-changing treatment landscape for both chronic hepatitis C and hepatocellular carcinoma, these questions are only going to grow. Treatment timing, interactions and the impact of one disease condition on the other are vitally important, though guidance generally remains non-specific, suggesting that we make these decisions on a case-by-case basis. We focus on the current evidence for managing these cases, depending on disease stage and treatment type.

Original languageEnglish
Article number28
JournalHepatoma Research
StatePublished - 2019


  • Hepatocellular carcinoma
  • direct-acting antiviral agents
  • hepatitis C virus
  • liver cancer


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