Management of adult idiopathic thrombocytopenic purpura

Ibrahim N. Nakhoul, Peter Kozuch, Mala Varma

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Idiopathic thrombocytopenic purpura (ITP) is defined as isolated thrombocytopenia without a clinically apparent cause. It is categorized as acute, chronic, and refractory. Its clinical presentation ranges from acute to insidious and the bleeding may vary from minimal to severe. The target platelet count with therapy is more than 30,000/μL in sedentary individuals. Since studies regarding therapies for ITP have been mostly uncontrolled case series, the treatment recommendations are largely derived from expert opinion. This review paper summarizes the data on available therapies for adult acute and chronic/refractory ITP. The therapies include splenectomy, steroids, intravenous immunoglobulin, anti-Rh(D), monoclonal antibodies, danazol, chemotherapy, plasma exchange, and others.

Original languageEnglish
Pages (from-to)136-144+153
JournalClinical Advances in Hematology and Oncology
Issue number2
StatePublished - Feb 2006
Externally publishedYes


  • Chemotherapy
  • ITP
  • Idiopathic thrombocytopenic purpura
  • Monoclonal antibodies
  • Splenectomy
  • Steroid


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