Management of acute food protein-induced enterocolitis syndrome emergencies at home and in a medical facility

Stephanie A. Leonard, Stefano Miceli Sopo, Mary Grace Baker, Alessandro Fiocchi, Robert A. Wood, Anna Nowak-Węgrzyn

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Objective: Acute food protein-induced enterocolitis syndrome (FPIES) is characterized by delayed repetitive vomiting after ingestion of a trigger food, and severe reactions may lead to dehydration, hypotension, and shock. We provide recommendations on management of FPIES emergencies in a medical facility and at home. Data Sources: This review summarizes the literature on clinical context, pathophysiology, presentation, and treatment of FPIES emergencies. Study Selections: We referred to the 2017 International Consensus Guidelines for the Diagnosis and Management of FPIES and performed a literature search identifying relevant recent primary articles and review articles on clinical management. Results: Management of FPIES emergencies in a medical facility is based on severity of symptoms and involves rehydration, ondansetron, and corticosteroids. A proactive approach for reactions occurring at home involves prescribing oral ondansetron and providing an individualized treatment plan based on the evolution of symptoms and severity of past reactions. A better understanding of the pathophysiology of FPIES and randomized trials on ondansedron and cocorticosteroid use could lead to more targeted treatments. Conclusion: Children with FPIES are at risk for severe symptoms constituting a medical emergency. Management of FPIES emergencies is largely supportive, with treatment tailored to the symptoms, severity of the patient's condition, location of reaction, and reaction history.

Original languageEnglish
Pages (from-to)482-488.e1
JournalAnnals of Allergy, Asthma and Immunology
Issue number5
StatePublished - May 2021


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