TY - JOUR
T1 - Mammalian non-classical major histocompatibility complex I and its receptors
T2 - Important contexts of gene, evolution, and immunity
AU - Chattopadhyay, Subhasis
AU - Pratheek, B. M.
AU - Nayak, Tapas K.
AU - Sahoo, Subhransu S.
AU - Mohanty, Prafulla K.
AU - Chattopadhyay, Soma
AU - Chakraborty, Ntiya G.
PY - 2014/4/1
Y1 - 2014/4/1
N2 - The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes. Moreover, these nonclassical MHC molecules are known to interact with CD94/NKG2 heterodimeric receptors to induce immune responses and immune regulations. This dual role of Qa-1/ HLA-E in terms of innate and adaptive immunity makes them more interesting. This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity.
AB - The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes. Moreover, these nonclassical MHC molecules are known to interact with CD94/NKG2 heterodimeric receptors to induce immune responses and immune regulations. This dual role of Qa-1/ HLA-E in terms of innate and adaptive immunity makes them more interesting. This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity.
KW - CD94/NKG2
KW - Human leukocyte antigen-E
KW - Major histocompatibility complex
KW - Qa-1
UR - http://www.scopus.com/inward/record.url?scp=84908542799&partnerID=8YFLogxK
U2 - 10.4103/0971-6866.142855
DO - 10.4103/0971-6866.142855
M3 - Review article
AN - SCOPUS:84908542799
SN - 0971-6866
VL - 20
SP - 129
EP - 141
JO - Indian Journal of Human Genetics
JF - Indian Journal of Human Genetics
IS - 2
ER -