Malondialdehyde-deoxyguanosine adducts among workers of a thai industrial estate and nearby residents

Marco Peluso, Petcharin Srivatanakul, Armelle Munnia, Adisorn Jedpiyawongse, Marcello Ceppi, Suleeporn Sangrajrang, Sara Piro, Paolo Boffetta

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Background: Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stress and reactive oxygen species, which interact with DNA and lipids, leading to oxidative damage and lipid peroxidation, respectively. Objective: We measured the levels of malondialdehyde-deoxyguanosine (dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in petrochemical workers, nearby residents, and subjects living in a control district without proximity to industrial sources. Design: We conducted a cross-sectional study to compare the prevalence of malondialdehyde-dG adducts in groups of subjects experiencing various degrees of air pollution. Results: The multivariate regression analysis shows that the adduct levels were associated with occupational and environmental exposures to air pollution. The highest adduct level was observed in the steel factory workers. In addition, the formation of DNA damage tended to be associated with tobacco smoking, but without reaching statistical significance. A non significant increase in DNA adducts was observed after 4-6 years of employment among the petrochemical complexes. Conclusions: Air pollution emitted from the Map Ta Phut Industrial Estate complexes was associated with increased adduct levels in petrochemical workers and nearby residents. Considering the mutagenic potential of DNA lesions in the carcinogenic process, we recommend measures aimed at reducing the levels of air pollution.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalEnvironmental Health Perspectives
Issue number1
StatePublished - Jan 2010
Externally publishedYes


  • Air pollution
  • Lipid peroxidation
  • Map Ta Phut
  • MdG adducts
  • Reactive oxygen species


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