Malignant external otitis: The shifting treatment paradigm

Daniel A. Carlton, Enrique E. Perez, Eric E. Smouha

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Importance Malignant external otitis (MEO) is an aggressive infection occurring in immunocompromised hosts. Increasing antimicrobial resistance is making the disease more difficult to treat. Objective Determine if there has been a shift in the microbiology and outcomes of MEO. Design A retrospective case series at a tertiary care institution. Setting Inpatient and outpatient tertiary care hospital. Participants 12 cases of recent MEO were reviewed. Main Outcomes and measures The primary outcome was progression of disease. Secondary outcomes were drug resistance and complications of MEO. Results Only 4 patients were cured of MEO. Four patients expired during the study period and at least one of these deaths was a direct result of the MEO. 7 patients developed Cranial nerve palsies, and 3 patients developed abscesses. Conclusions Select cases of MEO now require multi-drug and long-term parenteral antibiotic therapy with extended hospital stays.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number1
StatePublished - Jan 2018


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