Malignant external otitis: The shifting treatment paradigm

Daniel A. Carlton; Enrique E. Perez; Eric E. Smouha

doi:10.1016/j.amjoto.2017.05.010

Malignant external otitis: The shifting treatment paradigm

Daniel A. Carlton, Enrique E. Perez, Eric E. Smouha

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Importance Malignant external otitis (MEO) is an aggressive infection occurring in immunocompromised hosts. Increasing antimicrobial resistance is making the disease more difficult to treat. Objective Determine if there has been a shift in the microbiology and outcomes of MEO. Design A retrospective case series at a tertiary care institution. Setting Inpatient and outpatient tertiary care hospital. Participants 12 cases of recent MEO were reviewed. Main Outcomes and measures The primary outcome was progression of disease. Secondary outcomes were drug resistance and complications of MEO. Results Only 4 patients were cured of MEO. Four patients expired during the study period and at least one of these deaths was a direct result of the MEO. 7 patients developed Cranial nerve palsies, and 3 patients developed abscesses. Conclusions Select cases of MEO now require multi-drug and long-term parenteral antibiotic therapy with extended hospital stays.

Original language	English
Pages (from-to)	41-45
Number of pages	5
Journal	American Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.amjoto.2017.05.010
State	Published - Jan 2018

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title = "Malignant external otitis: The shifting treatment paradigm",

abstract = "Importance Malignant external otitis (MEO) is an aggressive infection occurring in immunocompromised hosts. Increasing antimicrobial resistance is making the disease more difficult to treat. Objective Determine if there has been a shift in the microbiology and outcomes of MEO. Design A retrospective case series at a tertiary care institution. Setting Inpatient and outpatient tertiary care hospital. Participants 12 cases of recent MEO were reviewed. Main Outcomes and measures The primary outcome was progression of disease. Secondary outcomes were drug resistance and complications of MEO. Results Only 4 patients were cured of MEO. Four patients expired during the study period and at least one of these deaths was a direct result of the MEO. 7 patients developed Cranial nerve palsies, and 3 patients developed abscesses. Conclusions Select cases of MEO now require multi-drug and long-term parenteral antibiotic therapy with extended hospital stays.",

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AU - Smouha, Eric E.

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N2 - Importance Malignant external otitis (MEO) is an aggressive infection occurring in immunocompromised hosts. Increasing antimicrobial resistance is making the disease more difficult to treat. Objective Determine if there has been a shift in the microbiology and outcomes of MEO. Design A retrospective case series at a tertiary care institution. Setting Inpatient and outpatient tertiary care hospital. Participants 12 cases of recent MEO were reviewed. Main Outcomes and measures The primary outcome was progression of disease. Secondary outcomes were drug resistance and complications of MEO. Results Only 4 patients were cured of MEO. Four patients expired during the study period and at least one of these deaths was a direct result of the MEO. 7 patients developed Cranial nerve palsies, and 3 patients developed abscesses. Conclusions Select cases of MEO now require multi-drug and long-term parenteral antibiotic therapy with extended hospital stays.

AB - Importance Malignant external otitis (MEO) is an aggressive infection occurring in immunocompromised hosts. Increasing antimicrobial resistance is making the disease more difficult to treat. Objective Determine if there has been a shift in the microbiology and outcomes of MEO. Design A retrospective case series at a tertiary care institution. Setting Inpatient and outpatient tertiary care hospital. Participants 12 cases of recent MEO were reviewed. Main Outcomes and measures The primary outcome was progression of disease. Secondary outcomes were drug resistance and complications of MEO. Results Only 4 patients were cured of MEO. Four patients expired during the study period and at least one of these deaths was a direct result of the MEO. 7 patients developed Cranial nerve palsies, and 3 patients developed abscesses. Conclusions Select cases of MEO now require multi-drug and long-term parenteral antibiotic therapy with extended hospital stays.

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Malignant external otitis: The shifting treatment paradigm

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