Maladie de Crohn jejuno-ileale diffuse: Une forme particuliere de la maladie?

Translated title of the contribution: Diffuse jejuno-ileitis of Crohn's disease: A peculiar form of the disease?

Ivan Touze, Corinne Gower-Rousseau, Bruno Grandbastien, Jean Claude Paris, Pierre Quandalle, Antoine Cortot, Jean Frédéric Colombel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background and aims - Diffuse jejuno-ileitis of Crohn's disease may be a homogeneous clinical subgroup. The aim of this work was to compare the demographic and clinical data at diagnosis and the initial treatments of patients with diffuse jejuno-ileitis of Crohn's disease and to the ones without this localization. Patients and methods - For demographic and clinical studies, 48 (32M/16F) incident cases of diffuse jejuno-ileitis of Crohn's disease diagnosed between 1988 and 1994 in the EPIMAD register were compared with 96 (48M/48F) controls diagnosed the same year. As far as for the therapeutic management, the 48 incident cases were compared with 48 controls. Results - Diffuse jejuno-ileitis constituted 3.3% of the total incident cases. Median age at diagnosis was significantly lower (20 vs 23 years, P=0.01) and an upper digestive involvement was more frequent (56% vs 34%, P=0.03) in patients with diffuse jejuno-ileitis. These patients were more often treated by total parenteral nutrition (43.8% vs 19.6%, P=0.01) or azathioprine (50% vs 20.8%, P=0.005). Azathioprine was also introduced earlier (20.7 vs 40.3 months, P=0.009). Surgery for resection was less often required in diffuse jejuno-ileitis than in controls (65.2% vs 99.8%, P=0.02) while more stricturoplasties were performed (52.9% vs 10%, P=O. 003); overall surgical rates did not significantly differ in the 2 groups. Conclusion - Our series suggest that diffuse jejuno-ileitis of Crohn's disease is a subgroup of patients characterized by a young age at diagnosis, with more frequent and earlier requirement for azathioprine.

Translated title of the contributionDiffuse jejuno-ileitis of Crohn's disease: A peculiar form of the disease?
Original languageFrench
Pages (from-to)307-311
Number of pages5
JournalGastroenterologie Clinique et Biologique
Issue number3
StatePublished - 1999
Externally publishedYes


  • Clinical
  • Crohn's disease
  • Diffuse jejuno-ileitis
  • Epidemiology
  • Treatment


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