Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis

Keyphrases

• Poor Outcome 100%
• Decompensated Cirrhosis 100%
• Acute-on-chronic Liver Failure 100%
• Emergency Granulopoiesis 100%
• High Risk 11%
• Neutrophils 11%
• Unmet Needs 11%
• CEBPA 11%
• Blood Transcriptomics 11%
• Eigengene 11%
• Failure Development 11%
• Immune Cells 5%
• Interleukin-6 5%
• Hospitalization 5%
• RNA Sequencing (RNA-seq) 5%
• Immunosuppression 5%
• Time-to-event Analysis 5%
• RNA-seq Data 5%
• Potential Biomarkers 5%
• Blood Count 5%
• Whole Blood 5%
• Pathogenic Role 5%
• Transcriptome 5%
• Lymphocyte Function 5%
• Transcriptomic Profiling 5%
• Downstream Targets 5%
• Cycling Cells 5%
• New Infections 5%
• Potential Identification 5%
• Gene Module 5%
• Weighted Correlation Network Analysis (WGCNA) 5%
• Biological Therapy 5%
• Neutrophil Differentiation 5%
• Neutrophilia 5%
• Blood Transcriptome 5%
• Function Features 5%
• Master Transcription Factor 5%
• STAT3 Gene 5%
• Cell Perturbation 5%
• Immature Neutrophils 5%
• Whole Blood RNA 5%
• Monocytic Myeloid-derived Suppressor Cells (M-MDSCs) 5%
• Cellular Module 5%
• Low-density Neutrophils 5%
• Blood Transcriptome Analysis 5%
• Mature Neutrophils 5%

Immunology and Microbiology

• Granulopoiesis 100%
• Cirrhosis 100%
• Neutrophil 71%
• Upregulation 42%
• STAT3 28%
• Transcriptomics 28%
• CCAAT Enhancer Binding Protein Beta 28%
• Immunocompetent Cell 14%
• Interleukin 6 14%
• RNA Sequence 14%
• Transcription Factors 14%
• Immunosuppression 14%
• Infectious Disease 14%
• Lymphocyte Function 14%
• Blood Cell Count 14%
• RNA Sequencing 14%
• Myeloid-Derived Suppressor Cell 14%
• Gene Expression Assay 14%
• Infection 14%