Making sense of the sweet taste receptor

Peihua Jiang, Emetine Maillet, Meng Cui, Roman Osman, Marianna Max, Robert F. Margolskee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Sugars, sweeteners and certain proteins all taste sweet. These chemically diverse compounds activate the same sweet receptor, a heterodimer of T1R2 plus T1R3. Humans and mice each detect the sweetness of sugars, but some compounds that are intensely sweet to humans are not sweet at all to mice. Heterologous expression of the mouse or human sweet taste receptors reproduces, respectively, the mouse or human response to sweeteners. Expression of mismatched combinations of human plus mouse T1R subunits, or of human/mouse chimeras of T1R subunits enabled us to identify portions of the sweet receptor required for responses to sweet ligands. Responsiveness to aspartame depends on the extracellular domain of human T1R2; brazzein depends on the cysteine-rich domain of human T1R3; the agonist cyclamate and the antagonist lactisole depend on the transmembrane domain of human T1R3.

Original languageEnglish
Title of host publicationSweetness and Sweeteners
Subtitle of host publicationBiology, Chemistry and Psychophysics
PublisherAmerican Chemical Society
Number of pages17
ISBN (Print)9780841274327
StatePublished - 4 Mar 2008

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918


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