Making a Hematopoietic Stem Cell

Michael G. Daniel, Carlos Filipe Pereira, Ihor R. Lemischka, Kateri A. Moore

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Previous attempts to either generate or expand hematopoietic stem cells (HSCs) in vitro have involved either ex vivo expansion of pre-existing patient or donor HSCs or de novo generation from pluripotent stem cells (PSCs), comprising both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). iPSCs alleviated ESC ethical issues but attempts to generate functional mature hematopoietic stem and progenitor cells (HSPCs) have been largely unsuccessful. New efforts focus on directly reprogramming somatic cells into definitive HSCs and HSPCs. To meet clinical needs and to advance drug discovery and stem cell therapy, alternative approaches are necessary. In this review, we synthesize the strategies used and the key findings made in recent years by those trying to make an HSC.

Original languageEnglish
Pages (from-to)202-214
Number of pages13
JournalTrends in Cell Biology
Volume26
Issue number3
DOIs
StatePublished - 1 Mar 2016

Keywords

  • Hematopoiesis
  • Hematopoietic stem cell
  • Reprogramming
  • Transcription factors

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